Our clinical research program provides patients with the opportunity to benefit from cutting-edge technology through numerous FDA approved clinical trials. Vascular residents are also encouraged to participate in our ongoing clinical and/or laboratory research. Please contact the division's clinical research team at 404.727.8217 for more information regarding our active clinical investigations and completed clinical investigations.



ACTIVE CLINICAL INVESTIGATIONS

Thoracic Aortic Aneurysms
Abdominal Aortic Aneurysms
Carotid Artery Disease
Lower Extremity Arterial Occlusive Disease



THORACIC AORTIC ANEURYSMS

	Medtronic Vascular, Inc. VALOR II: The Valiant Thoracic Stent Graft Clinical Study
	Cook Incorporated: Zenith TX2 Thoracic TAA Endovascular Graft
	W.L GORE & Associates: Evaluation of the GORE TAG Thoracic Endoprosthesis for Treatment of Descending Thoracic Aneurysms TAG 03-03
	W.L GORE & Associates: Evaluation of the GORE TAG Thoracic Endoprosthesis for the Treatment of Complex Pathology of the Descending Thoracic Aorta (Clinical Study) TAG 04-01
	W.L GORE & Associates: Treatment IDE for the use of the GORE TAG Thoracic Endoprosthesis for the Treatment of Subjects with Descending Thoracic Aortic Aneurysms Requiring Surgical Repair TAG 04-02

ABDOMINAL AORTIC ANEURYSMS

	W.L. GORE & Associates: A Clinical Study Evaluating the Use of the GORE EXCLUDER® Bifurcated Endoprosthesis – 31mm in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms Protocol Number:AAA-03-02
	W.L GORE & Associates: Stent Treatments for the Aorta Registry (STAR)
	W.L GORE & Associates: A Clinical Evaluation of the GORE EXCLUDER® Bifurcated Endoprosthesis – Low Permeability in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms AAA-04-04
	LeMaitre Vascular, Inc: Clinical Study of Aneurysm Exclusion using the EndoFit® Aorto-Uni-Iliac Endoluminal Stent Graft
	VA Cooperative Studies. OVER Trial: A Randomized Controlled Trial to Compare Elective Open vs Endovascular Repair of Abdominal Aortic Aneurysms (AAA)
	CardioMEMS, Inc: Feasibility Evaluation of the CardioMems Abdominal Aortic Aneurysm Pressure Sensor System. APEX Study (Acute Pressure Measurement to Confirm Aneurysm Sac Exclusion)
	Aptus Endosystems: STAPLE-1 Feasibility Study to Evaluate the Aptus Endovascular AAA Repair System

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CAROTID ARTERY DISEASE

	Abbott Vascular Devices: The EXACT Study: Emboshield and Xact Post Approval Carotid Stent Trial using the Emboshield® BareWire™ Rapid Exchange Embolic Protection System and Xact® Rapid Exchange Carotid Stent System
	W.L GORE & Associates: The Embolic Protection with Reverse Flow (EMPiRE) Study of the Gore Neuro Protection System in Carotid Stenting of Patients at High Risk for Carotid Endarterectomy
	NIH/NINDS: Carotid Revasclarization Endarterectomy vs Stenting Trial (CREST) Protocol 99-705

LOWER EXTREMITY ARTERIAL OCCLUSIVE DISEASE

	Edwards Lifesciences LLC: A Randomized Study Comparing the Edwards Self-Expanding Life Stent vs. Angioplasty-alone In Lesions Involving the SFA and/or Proximal Popliteal Artery
	Sanofi-Synthelabo: Mascot: Double-blind, Randomized Trial of SL650472 for 24-week Improvement of Walking Distance in Patients with Stage II Peripheral Arterial Disease. (Sanofi ACT4791 Protocol)

ENDOVASCULAR TREATMENT OF ABDOMINAL AORTIC ANEURYSM

Guidant, Clinical Study of the Tube EGS® as Compared to the Standard Surgical Procedure in the Treatment of Abdominal Aortic Aneurysms (AAA) EnAct-T Protocol #9501, January 1996-7/31/02

Guidant, EnACT-B: A Phase II, Clinical Study of the Bifurcated EGS System as Compared to the Standard Surgical Procedure in the Treatment of Abdominal Aortic Aneurysms Protocol # 9601, April 1997-5/31/02

Guidant, A Phase II, Clinical Study of the Aortoiliac EGS System as Compared to the Standard Surgical Procedure in the Treatment of Abdominal Aortic Aneurysms Protocol # 9602, 3/17/97-7/31/02

Guidant, Clinical Study of the Ancure™ Tube and Bifurcated Systems Extended Indications Evaluation Protocol #9801, 5/1/98-7/31/02

W. L. Gore & Associates, Inc. A Clinical Study Comparing Use of the Modified Bifurcated EXCLUDER Endoprosthesis to Open Surgical Repair in the Primary Treatment of Infrarenal Abdominal Aortic Aneurysms (AAA)

W. L. Gore & Associates, Inc. A Clinical Study Comparing Use of the Thoracic EXCLUDER Endoprosthesis to Open Surgical Repair in the Primary Treatment of Descending Thoracic Aneurysms (TAG)

World Medical Manufacturing Corporation, Compassionate Use Of The Talent Endoluminal Spring/Stent System In Patients With Thoracic Aortic And Abdominal Aortic Aneurysms

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CAROTOD STENT TRIALS

eV3, Carotid Revascularization with eV3 Arterial Technology Evolution(CREATE) Trial

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ENDOVASCULAR TREATMENT OF VASCULAR INJURIES

Corvita, Inc., Corvita Graft for Traumatic Arterial Lesions, 3/14/96 – 8/31/97

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ENDOVASCULAR TREATMENT OF ARTERIAL OCCLUSIVE DISEASE

Corvita, Inc., Corvita Graft for Occlusive Arterial Lesions, 9/1/97-8/31/98

Nuvelo, Inc. PHASE 3, Multicenter, Multinational, Randomized, Partial Double-Blind, Placebo-Controlled Study to Evaluate the Efficacy and Safety of Alfimeprase in Subjects with Acute Peripheral Arterial Occlusion (NAPA-2)

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OPTIMIZING SURGICAL TREATMENT OF THORACOABDOMINAL AORTIC ANEURYSM

Schering Plough Research Institute, Safety and Tolerance of Intravenous fHuIL-10 (SCH 52000) in Patients Undergoing Elective Thoracoabdominal Aortic Aneurysm Repair, 11/1/97-11/10/99

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MEDICAL MANAGEMENT OF LOWER EXTREMITY PERIPHERAL VASCULAR DISEASE

(Physician Initiated) A Pilot Study of the Efficacy of Losartan on Walking Distances in Patients with Intermittent Claudication due to Peripheral Arterial Occlusive Disease

Sanofi-Synthelabo, Research in a joint development program with Bristol-Myers Squibb: Clopidogrel for High Atherothrombotic Risk and Ischemic Stabilization, Management and Avoidance (CHARISMA), Protocol Number EFC4505

Pfizer Inc., A Double Blind, Placebo Controlled, Parallel Group Study of the Effects of Zoniporide on Perioperative Cardiac Events in High Risk Subjects Undergoing Noncardiac Vascular Surgery, Protocol A3181 00 7, 1/1/02-7/01/03

Pfizer Inc., A Double-Blind, Randomized, Placebo- Controlled, Dose-Ranging, 26-Week Study to Assess the Safety and Efficacy of CI-1023 (AdGvVEGF121.10) in Peripheral Arterial Disease Patient's with Severe, Disabling Intermittent Claudication, Protocol 1023-005

United Therapeutics, A Multicenter, Double-Blind, Randomized Parallel Placebo-Controlled Study of the Safety and Efficacy of Chronic Oral Beraprost Sodium in Patients with Intermittent Claudication (Fontaine Stage II Peripheral Arterial Occlusive Disease), 3/31/00-5/01/02

Chiron Corporation, Phase II, Randomized, Multicenter, Double Blind, Placebo-Controlled, Regimen Finding Study to Evaluate the Safety, Pharmacokinetics, and Efficacy of Recombinant Fibroblast Growth Factor-2 (rFGF-2) in Subjects With Stable Intermittent Claudication (IC) due to Peripheral Arterial Disease (PAD), 1999-2000

Alpha Therapeutic Corporation, Intravenous Lipo-PGE1 Therapy in Patients with Ischemic Ulcers due to Peripheral Vascular Disease, 3/14/94-2/28/97

Berlex, Inc., Oral Iloprost in Peripheral Arterial Occlusive Disease (Fontaine Stage I/II), 11/18/96-11/17/97

Berlex, Inc., Oral Iloprost in Peripheral Arterial Occlusive Disease (Fontaine Stage III/IV), 1/1/98–12/31/99

Ortec Intl., A Randomized Pilot Study to Examine the Safety and Healing Trends of a Collagen Matrix Containing Allograft Cells for the Treatment of Neuropathic Foot Ulcers in Patients with Diabetes Mellitus Protocol 99-001/OR, 3/01/00-2/28/02

Abbott, A Phase 11 Dose Ranging Trial of Intra-Arterial Recombinant Prourokinase (ABT 187) vs. Urokinase (ABT 790) in the Treatment Of Peripheral Arterial Thromboembolic Occlusions (PURPOSE), 1996-98

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NOVEL BIOLOGICS AND TISSUE ENGINEERED PRODUCTS FOR VENOUS AND DIABETIC ULCERS

Kimberly-Clark, Gene Expression Profiles in Chronically Wounded Tissue: A Pilot Study, 1/1/01-1/1/02

Magainin, Inc., MSI-78 Topical Cream vs. Oral Ofloxacin in the Treatment of Infected Diabetic Ulcers, 9/1/94-10/31/96

Genzyme, Inc., Evaluation of rTGF-b2 for the Treatment of Diabetic Foot Ulcers, 10/1/95-9/30/96

Organogenesis, Evaluation of a Living Skin Equivalent for the Treatment of Diabetic Foot Ulcers, 6/23/97-6/22/99

Human Genome Sciences, A Randomized, Double-Blinded, Parallel-Group, Placebo- Controlled, Multicenter Study of Keratinocyte Growth Factor (KGF-2) to Evaluate the Safety and Efficacy of Acceleration of Wound Healing in Chronic Venous Ulcer Patients Following Topical Administration to the Wound Twice Weekly for Twelve Weeks, 3/1/99-2/28/01

Cohesion Technologies, A controlled randomized multicenter to assess the safety and effectiveness of CoSeal surgical sealant applied to anastomoses of PTFE grafts for arterial reconstruction, 2000-01

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HEMODIALYSIS AV ACCESS GRAFT MANAGAMENT

Boston Scientific Comparison of the S.E.T. Catheter Thrombectomy System vs. Thrombolytic Treatment of Hemodialysis Graft Thrombosis, 1998-99

IMPRA, subsidiary of C.R. Bard, Inc.; Prospective, Multi-Center Evaluation of the Venaflo ePTFE Vascular Graft as Compared to IMPRA ePTFE Vascular Graft in Hemodialysis Applications, 1998-99

Novo Nordisk Pharmaceuticals, Inc., Double-Blind, Placebo Controlled, Randomized Within Each Dose Level, Single Dose, Dose-Escalation Study Assessing the Tolerability and the Antithrombin Effect of FFR-rFVHa after AV-shunt Implantation in Hemodialysis Patients, 1997-98

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