Faculty Profile

Muralidhar Padala, PhD

Muralidhar Padala, PhD

Assistant Professor, Division of Cardiothoracic Surgery, Emory University (Primary)

Assistant Professor, Department of Biomedical Engineering, Georgia Institute of Technology (Secondary)

Principal Investigator, Structural Heart Disease Research and Innovation Lab

Telephone: 404.251.0651

Email: spadala@emory.edu

Year Joined Emory as a Faculty Member: 2010

Biography

An engineer by training, Dr. Padala is currently focused on studying the biomechanics and mechanobiology of heart valve disease and heart failure. He received his BS in mechanical engineering from Osmania University in India in 2004, and an MS in mechanical engineering and PhD in bioengineering from Georgia Tech in 2010. Since joining Emory and establishing his independent laboratory in 2010, his focus has been on studying in-vivo heart valve and cardiac mechanics in pre-clinical models. In 2012, he spent one year at Imperial College London on a Leducq Fondation Career Development Award. He trained under Prof. Sir. Magdi Yacoub, a pioneer in cardiac transplantation and heart valve tissue engineering.

Dr. Padala's Current Research Interests:

Basic Science: With the objective of discovering the optimal timing of heart valve repair/replacement, Dr. Padala is studying the impact of mitral valve and tricuspid valve regurgitation on structural and functional remodeling of the heart. This work was initially funded by a Leducq Foundation Career Development Award received by Dr. Padala in 2011 that lasted until 2014. Current funding is provided by a Scientist Development Grant he received from the American Heart Association (2014-2018).

Clinical Science: By studying the inadequacies of existing repair methods, Dr. Padala is working to develop new techniques to repair the mitral and tricuspid valves and the injured left ventricle associated with these valve diseases. Funding has been provided by the Carlyle Fraser Heart Center (2012-2015).

Innovations: While essential, the process of moving new concepts from the lab to the patient can be protracted and iterative. Dr. Padala's lab is dedicated to translating scientific concepts into patents and prototypes and is conducting the pre-clinical work required to demonstrate the safety and efficacy of the lab's innovations. This work is funded by an NIH STTR grant (2012-2014), the Georgia Research Alliance (2012-2015), and the Wallace Coulter Foundation (2011-2013). Dr. Padala received the Innovation of the Year award from the Emory Office of Technology Transfer in 2011 for achievements in this area.

Visit Dr. Padala's website for his Structural Heart Research and Innovation Lab.

Publications

View Dr. Padala's publications in PubMed.

Affiliations

  • Structural Heart Disease Research and Innovation Laboratory, Emory University School of Medicine

  • Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology

Education

  • Research Fellowship, Imperial College London, 2012

  • PhD in Bioengineering, Wallace H. Coulter Department of Biomedical Engineering, Georgia Institute of Technology, Atlanta, GA, 2010

  • MS in Mechanical Engineering, Georgia Institute of Technology, 2008

  • BS in Mechanical Engineering, Osmania University, India, 2004

Honors and Awards

  • Scientist Development Grant, American Heart Association, 2014

  • Leducq Foundation Career Development Award, 2012

  • Emory University Innovation of the Year Award, 2011
  • Gandy Diaz Teaching Fellowship, Georgia Institute of Technology, 2009

  • American Heart Association Pre-Doctoral Fellowship, 2008

Current Organizational Memberships

  • American Heart Association

  • Biomedical Engineering Society

  • Society of Heart Valve Disease

Basic Science Research Interests

  • Mechanisms of mitral and tricuspid valve disease

  • Heart chamber remodeling in valve disease

  • Modulating myocardial mechanics to decelerate heart failure

Clinical Research Interests

  • 3D echo and MRI imaging to map cardiac and valve mechanics

  • New techniques for valve and cardiac repair

Translational Research Interests

  • Transcatheter heart valve repair and replacement

  • Multi-modality imaging to guide beating heart valve repair